Dr. Tundun Williams - Weeks 2 and 3 in Ogbomoso, Nigeria

The literature states that the prevalence of G6PD deficiency in Africa is anywhere between 15-30%.

Risk factors for hemolysis include use of mentholated products in the first six months of life, illness, certain drugs (e.g., Primaquine, sulfa drugs, Quinine) and fava beans (the jury is still out with regards to whether Nigerians eat fava beans).

We screened children at schools, churches and small villages. The screen included asking simple screening questions and collecting blood samples from children under the age of 16 years old. Samples were processed back at the hospital lab.

By the end of the third week, we had exceeded our goal of screening 1,000 children.

Initial analysis of our data shows a prevalence of 10-19%; differences in prevalence appeared to be related to ethnic group.

Parents of deficient children will soon be sent notification letters telling them what to avoid and how to recognize symptoms of hemolysis. Lab personnel have been taught how to do the simple G6PD screening test. We hope they will continue to screen children long after we leave.

The Baptist seminary elementary school, one of the first sites we visited to perform G6PD screens.

Ajinapa village; more children to screen for G6PD

Adodo village. These boys were insistent on striking fighting poses.

Ilota village school

Our host, Dr. Daniel Gbadero, speaks to children at Ayegun Baptist Church.

At Baptist Medical Center Staff School. This is Samuel, looking very sharp in his school uniform (the bowtie is optional, and as you can see, is worn by only those young men with discerning taste). You wouldn't know it from this picture, but Samuel is a giggler. He was particularly amused when I asked him if he had ever had tea-colored urine.

When the generator was not running, the power supply was unpredictable. Here, Troy Lund and I are running hematocrits on a battery-operated Hemocue machine by lantern light.

We used the fluorescent screening method for G6PD deficiency. Patients who have adequate G6PD activity produce NADPH, which fluoresces under long wave UV light. The spots that do not fluoresce represent patients that are G6PD deficient.

Ogbomoso, a town of just over 1 million inhabitants, is located in Oyo State (in Yoruba-land), about 150 miles north of Lagos.

Photo courtesy Google Maps and Wiki Commons

Like all other Yoruba towns, there is a story behind the origins of Ogbomoso. It is said that a mighty warrior named Elemoso once habitually terrorized the inhabitants of present day Ogbomoso.

The people got fed up with being pillaged and decided to send a warrior of their own to defend their city.

This warrior fought with and beheaded Elemoso.

The alaafin (king) of Oyo heard of this feat and was impressed. He dubbed the warrior "Ogbori Elemoso" (he who beheaded Elemoso) and crowned him soun (regional king) of his hometown.

Over the years, the name of the town, originally Ilu Ogbori Elemoso (the place of origin of Ogbori Elemoso), has contracted to just Ogbomoso.

We chose Ogbomoso as the site for the G6PD deficiency study because of Tina (Slusher)'s long-standing ties with the Baptist Medical Centre, where we have guaranteed access to a lab.

Dr. Tundun Williams - Week 1 In Lagos, Nigeria

Lagos is home to over 7 million people who call themselves "Lagosians". They are kind of like the New Yorkers of Nigeria. They dress to impress, drive... how shall I put this...purposefully, and are all vying for a bit of the wealth that is for the making in this city which remains the business capital of Nigeria.

Lagos is inhabited by the uberrich, who live in sprawling mansions on gated estates, as well as the destitute, who make do in shacks that house up to four families and have one communal bathroom.

To say that the wealth in this city is unequally distributed is stating the obvious.

I spent the majority of my time this week at the Massey Street Children's Hospital, a government-run pediatric hospital in inner-city Lagos.

I soon learned that the action at Massey was in the ED, a two-room facility on the second floor of the outpatient building, which was located across the street from the inpatient department.

After nearly losing my life trying to cross the street while dodging public minivans (danfos), three wheeled cabs (maruwas) and motorcycles (okadas) on my first day at Massey, I mastered the art of road-crossing in Lagos, which consists of venturing forth at a time when the road is relatively clear and then holding your ground in the face of any oncoming traffic until you are given the right of passage. You must show no fear.

The in-patient building at Massey

The busy street between the two buildings at Massey

The doctors in the ED were glad to have me on board. Part of the art of practicing medicine in the developing world is learning to improvise, and improvise I did. I performed an LP on a 6yo with a 20-gauge needle (stylet, schmylet), used the elastic band on the bottom of a pair of gloves for a tourniquet and did many other things that would never have crossed my mind in the US. 

I saw several cases of very classic kernicterus, a case of cholera and malaria galore.

Since Massey is a government-run facility, basic supplies like gloves, IV cannulas, syringes and needles can be obtained for free from the hospital pharmacy with a doctor's written prescription.

If the pharmacy happens to be out of stock, however, patients are responsible for purchasing their own supplies and bringing them to the hospital. The cost of medical care can be mammoth and is one of the factors that prevents the average Nigerian from seeking timely treatment.

Inside Massey's ED

A toddler at Massey with left lower lobe pneumonia. The cuts had been made in his village when he started coughing and then complained of abdominal pain.

When I was not at Massey, I pitched in to help Tina (Slusher) with her sunlight phototherapy study. At the end of this week, I will head to the small town of Ogbomoso, where I will be spending the majority of my time.

Dr. (Henk) Vreman and his helpers setting up the sunlight phototherapy tent frame

Down time at an ice cream parlor