Showing posts with label Partner Site: Uganda. Show all posts
Showing posts with label Partner Site: Uganda. Show all posts

Wednesday, April 8, 2015

Megan Hilger's Reflections on Her Experience at Mulago


 Posted on behalf of Megan Hilgers, Pediatric 2nd Year Resident

Hello from Kampala, Uganda!


As my time here is nearing the end, I am thankful for the experiences I've had, relationships I've formed and vast amount of knowledge I've obtained. I spent my first week working on research in the hematology lab with Dr Troy Lund looking at markers of oxidative stress in G6PD deficiency. My remaining time was spent doing clinical work. 
Megan Hilgers with Derrick, the Hematology Lab Tech
Most of my clinical time was spent in the resuscitation room of the Acute Care Unit.  This unit is where the Pediatric ED, PICU and a transition ward are located.  I worked alongside the Ugandan residents, interns and medical students. As you would expect from the name, the patients brought into the resuscitation room are critically ill and require rapid interventions.  After patients are stabilized they are transferred to the PICU or ward where we continue to follow them with the team. The most frequent conditions we care for are sepsis, respiratory failure from pneumonia, severe acute malnutrition, hyperbilirubinemia and severe anemia. Oftentimes, these are in the setting of sickle cell anemia, TB, HIV or chronic malnutrition. Not only have I gained knowledge of these diseases and complications but I've improved my exam skills, procedure skills and even my ability to read blood smears. As a resident in the resuscitation room, I provided full spectrum care and I can now draw blood, place IVs, place I/O's, reconstitute and draw up meds, mix IV fluids and run a code with a lot more confidence.  I greatly enjoyed the mutual collaboration with the Ugandan residents as we discussed various patients and how management differs in the US. 
Ugandan residents with Megan Hilgers and a visiting Anesthesia resident from Stanford
Resources and healthcare staff are stretched thin in the hospital and posed many challenges that often fell to the parents/caregivers. Parents are relied on to monitor their child at bedside, administer medications, purchase certain medical supplies- such as blood culture bottles, pick up test results from the lab and even go to a nearby pharmacy to purchase inpatient medications when the unit is out of stock. Parents form a supporting community together within the unit and I often witnessed mothers teach each other how to express breast milk, use NG tubes, share meals with those in need and care for abandoned or orphaned children.

This is a great setting for residents interested in learning about management of critically ill patients in a hospital setting with limited resources.  There were a lot of opportunities for hands on management and teaching students and other residents.  It was very humbling and I cannot express strongly enough how grateful I am for this experience.

Observations from the Special Care Nursery at Mulago


Posted on behalf of Sarah McIntire, MedPeds 4th year resident

Eighty. That’s probably a good estimate of the average census in the Special Care Nursery at Mulago Hospital in Kampala, Uganda. On busy days, the number of infants can rise over 100. Clearly, there’s no such thing as a cap on the number of admissions we can take in one day, let alone a couple of hours. Here, the babies are divided into two rooms: preterm and term. Preterm infants can be anywhere from roughly 26-28 weeks (here, viability is typically considered 28 weeks), and often come in multiples – twins, triplets, even one set of quadruplets! Term infants can present with problems ranging from low Apgars at birth or respiratory distress, to asphyxia, seizures, or severe sepsis. As Mulago is a major referral center and a government run hospital, many infants are transferred in for complex management or simply because their parents cannot afford step-down nursery care at a private hospital.


The Special Care Nursery, where I work is quite different from the NICU I have become accustomed. There are no ventilators, only CPAP. There are very few continuous infusion pumps. Phototherapy is limited, and labs take about a day to turn around, so if an infant appears jaundiced, they are often just brought to a separate isolette and squeezed together under the lights. 

On my first day in the SCN, I felt overwhelmed by the sheer number of patients, and the limitation of resources. I could only think of what I wouldn’t give for a ventilator, or even just a quick CBC. At first, it was so hard to see past the differences between NICUs in the United States and here in Uganda. But, just like any new rotation back home, I waded right in, and started to realize that just because the care of newborns here is different, that doesn’t make it bad. It’s more about realizing how to make use of the tools you have available. 

Sarah and Kendahl with the Special Care Nursery Nurses

I learned to rely on mothers, who act as bedside nurses, and who don’t need a nursing degree to tell you that their child is too warm, or is breathing funny, or has a distended abdomen. I diagnosed a trachoesophageal fistula on my third day, after learning to place nasogastric tubes and having one that just wouldn’t go into the belly. Chest X-ray confirmed the TE fistula, and surgery was there the next day and ultimately took the child to the OR for repair. Just like back home (although perhaps without a CT scan or prenatal ultrasound).

But the most amazing thing to me about the Special Care Nursery goes beyond the medicine. My contribution of prescribing antibiotics or advancing feeds paled in comparison to the absolute love and devotion of the parents and families caring for these infants. I saw a mother, after breastfeeding her own child, pick up an abandoned infant awaiting placement, and, gently holding him, feed him formula from a syringe. She could have (and should have) been resting, but to her it was more important to care for this child who had been left behind. Another infant, whose mother died in child birth, was cared for lovingly not by his parents, or grandparents, but by his paternal aunt who gladly purchased formula to feed him, and stayed for days in the hospital until he was ready to discharge.



Special Care Nursery Nurses with Kendahl and Sarah

In a place where there can be so much tragedy (on reading the death log, it appears that about two or three infants die daily in SCN), it’s easy to feel disheartened. But on the eve of leaving, I can only say that I’m overwhelmed be the love and gratitude of the families and nursing staff here. It’s been an experience I’ve been lucky to have, and I look forward to more to come in the years ahead.

Thursday, April 3, 2014

First Patient Enrolled - Nate Herr (PL2)

Posted on behalf of Nate Herr (PL2)

With nearly perfect triumphal timing, it's my final week here and we just enrolled the first patient.  The process went smoothly, and in observing it all, it felt good see the family acting quite content and pleased to be receiving quality care and attention to detail both now and over the next year. 

They weren't the only ones pleased.  Many members of the NDI study team stopped by to say hello; from the lab technicians to the home visit coordinators.  The first enrollment is always a big day!

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GHU NDI Project Director, Ruth Namazzi, and Medical Officer, Denis, go over the enrollment forms in the consultation room.  (patient and family not photographed)

Also, I must note that Ruth is an excellent Ugandan pediatrician and is the Project Director here for the NDI study.  If you're in Minnesota this month you'll have the chance to meet her on April 29th when she presents her results on "Change in Hemoglobin concentration of Children with Severe Anemia at Mulago Hospital: A Prospective study."  It's her first time visiting Minnesota and the presentation will be at Dr Cindy's house at 6:30pm.




Monday, March 31, 2014

Nate Herr (PL2) on Getting an R01 Study Launched

Posted on behalf of Nate Herr (PL2)

After the safari, I returned to my routine of rounding in the PICU and stabilization room 2-days a week.  The remaining days of the week were dedicated to the various and many research study tasks surrounding getting a new R01 study launched.  This study will follow a spectrum of children admitted with severe malaria-- taking detail to discover more about the causes and outcomes of the different types; Coma, Seizures, Anemia, Acidosis, and Prostration.

Chandy John, Director of the Division of Global Pediatrics at UMN, had arrived in Uganda while I was out on safari.  In the next 3 weeks that he was here he facilitated meeting after meeting on his multiple clinical studies here-- including the NDI study I've been working on and described briefly above.

To answer a question, you need data.  And to get data you need forms.  The forms for our study collect somewhere around 7,000 variables per patient.  With our goal to take in all comers with severe malaria, we are expecting a lot of variables and a short and fast enrollment period-- both of which called for efficiency in the data collection and verification process.

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Karen Hamre, MPH, a PhD candidate at the UMN and current Fogarty Fellow, arrived 2 weeks ago and brought her skilled eye for detail and perspective of data analysis to the group.  It took almost a weeks worth of revisions and multiple rounds of feedback from everyone.  We spoke with everyone from the bedside nurses to the principle investigators to create a set of forms that we believe will efficiently and accurately collect the information we'll need. While it brought on headaches, it was great to have the many perspectives involved early on before the actual roll our of the study.

At the end of Chandy's time here, we weren't yet ready to enroll any patients, but we had made much progress in ensuring that the process would be smoother when it happens.  That last weekend he was here, the Global Health Uganda staff from across the country met for their annual retreat, and ventured out to an island in Lake Victoria.

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For most it was their first time at the island, and for many it was their first time on a boat.  With the entire GHU staff at the island you soon saw how they were a big family, enjoying the company and friendships build over time as the NGO approaches 15 years.  It's been a great privilege to work with them as it's apparent to all that they strive for excellence in whatever their task or role.

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The retreat did it's job in bringing rest and relaxation, something we needed with the multiple studies set to launch this spring.



Monday, March 24, 2014

Nate Herr's (PL2) Safari Story in Pictures

Posted on behalf of Nate Herr (PL2)

Hello again from Uganda!  I realize now that it's been a month since last checking in with our blog-- sorry about that!  I've been quite busy with a few things.  Chandy John has been on site and we've had productive meetings, and have been working on editing of forms to make our data collection more efficient.  Look for an upcoming post with more details.  

Since arriving back in mid-February for my 2 month rotation there was time to fit in a visually breathtaking safari.  

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I took some of my PTO in early March when Abby came to visit for a week. While we did spend a couple days around Kampala and at the Mulago Hospital, we first went up north on a 3-day safari.  Our main stops along the way were the Ziwa Rhino Sanctuary, where they're reintroducing them back into their natural habitat after being poached to elimination years ago, the big Murchison Falls Game Park, and the Budongo Forest for chimp tracking.  

Pictures say it all, so here they are! 

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Sunrise

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Rhinos resting in Ziwa Rhino Sanctuary

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A view of the Murchison Falls Game Park

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Antelope at the Murchison Falls Game Park
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An elephant at the Murchison Falls Game Park

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Giraffes at the Murchison Falls Game Park

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A hippo at the Murchison Falls Game Park

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Warthogs at the Murchison Falls Game Park

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Cranes at the Murchison Falls Game Park

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A crocodile at the Murchison Falls Game Park

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A mahogany tree

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A chimpanzee at the Budongo Forest

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Hope you enjoyed the photos!
-Nate



Thursday, February 27, 2014

Nate Herr (PL2) on Rafting and Brainstorming Implementation Research on the Nile

Posted on behalf of Nate Herr (PL2)

Beth Thielen invited me to try rafting with her this past weekend. (Beth is in the UMN Med-Peds program and is here working on the adult side of Mulago hospital on the ASTRO-CM trial with Dr. Boulware).  

With a few recommendations we decided to go with Nile River Explorers, an established rafting company here in Uganda.  Our raft guides, safety kayakers, etc, were all Ugandan, who have grown up into and thrived in the development of adventure tourism and sports.  Several of them, including our raft guide Juma, have competed at the international level in whitewater kayaking-- representing Uganda and Africa all through the energy of waterfalls and rapids in the backyard of their home village.

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The fun and adventure of rafting with excellent guides

By the end of the day we were exhausted, sun burnt, and winded from the three times our raft flipped in the rapids. But, all-in-all we were glad to be able to experience the thrill of the Nile river rapids.  These rapids have been sequentially disappearing with each installment of hydro-electric dams on the Nile, built to fill the need of reliable electricity in a developing country. A third dam is currently being proposed and depending on the height, additional habitat, communities, rapids, and tourism economies will be displaced or eliminated.  A petition is circulating both in hard copy in communities and online internationally to encourage the building of a smaller hydro-dam that would preserve the remaining falls and rapids on the river.

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Flat stretches of water were time for discussion and brainstorming

On the flat stretches between the rapids, we talked these issues of the Nile and more.  I also found out that it's hard to escape healthcare all together, even on your weekend off.  The two guys in the front of the boat were logisticians with MSF, in Uganda for a 2-week training session.  On the water and in the rafting truck we were discussing the challenges behind ensuring a cold-chain to deliver vaccines and the future promises of mHealth, the later which got me thinking-- a lot. mHealth is a broad term to describe mobile phone technology interfaced with healthcare and I see great potential for it here and elsewhere around the world.  If anyone has any experience or ideas on mHealth, please email me. It's hard to imagine future implementation research without it.

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Getting a bit wet after one of those flat stretches



Friday, February 21, 2014

Neuro-developmental Impairment in Malaria - post from Nate Herr (PL2)

Posted on behalf of Nate Herr (PL2)

I've alluded to some of the pediatric clinical research and
collaboration happening here in Kampala, it's really quite extensive and
thorough.  I'll do my best to summarize.





Malaria has long been a common disease in the equatorial tropics.
 It has a spectrum of severity, depending on the type of malaria one is
infected with and the age and health of the person infected.  The most
severe form of malaria is cerebral malaria which involves a patient in
coma and is fatal if the malaria is not treated.  This is thought to be
from the parasitized red blood cells sequestering in the blood flow to
the brain or due to inflammation, the answer is not yet clear.




Earlier, the same collaboration group with UMN and Mulago Hospital,
studied and compared two types of severe malaria.  One that I
mentioned, Cerebral Malaria, and Severe Malaria with Anemia.  They
followed the children through their illness and after they went home.
 They did continued EEGs tracking seizures, neuropsych and cognition
testing and found that children with anemia and no initial brain
involvement with their malaria still had deficits and disability down
the road.  These disabilities are a big problem in Uganda and
sub-saharan Africa and already the research group here is studying to
see if rehab programs can help children regain their abilities.



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What is about to start is a broader look at children with milder
forms of malaria to see if they also have disability from it.  In this
study, blood tests will also be done to look for clues as to what is
actually causing it.  Home visits and clinic visits will again follow
the children after their initial illness.




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Ahmed, Denis (our two medical officers with the study) and Dr. Postels

Our Ugandan Medical Officers are a critical part of this.  We held a training session today with Dr Doug Postels,
our Michigan State collaborator.  He lectured on the neuro exam then
afterwards the medical officers practiced, asked questions, and gave
much needed feedback on the forms and documentation that we've been
editing and creating these last weeks.




Every day I'm learning another piece of what it takes to get good
information to answer good questions for the betterment child health
care.  Nothing is ever simple and straightforward and the best insight
comes from looking at the problem from all angles-- with medicine being
only one of the angles.


Wednesday, February 19, 2014

Nate Herr (PL2) tells us about The Container

Posted on behalf of Nate Herr (PL2)

This
is the building we affectionately call 'The Container" because, well,
it's a shipping container.  Granted, it has a few upgrades since its
shipping days including a roof, windows, WiFi, a water cooler, and
thankfully an oscillating fan. 

The Container.JPG


This is one of the hubs of research collaboration with
Makerere University in Uganda, the University of Minnesota, and Michigan
State University.  In it you'll find medical students from the UMN--
Nick Sausen is here putting together donated EEG machines to help better
define EEG changes in cerebral malaria and correlate it with the
neuropsych testing that's being done.  Remember Tundun Williams?  She
graduated from our Peds Residency last year and has been here since on a
Fogarty Fellowship working on a clinical trial regarding sickle cell
disease treatment in Africa.


While there's no room for me in the container, I'm often working nearby with others in the Global Health Uganda team
on their both ongoing and upstarting malaria research projects.  More
on that later. for now, please take a moment and send some cold Minnesota vibes to those working in the container.



Tuesday, February 18, 2014

[one hundred and] eighty degrees difference - Nate Herr (PL2 arrives in Kampala)

Posted on behalf of Nate Herr (PL2)

Leaving Minneapolis, I left behind a consistently cold winter. averaging temperatures in the single digits.  A day's worth of flying later, and a much more ambient temperature, greeted me in Kampala.  As it's in the 70s and 80s here. Gone are the snow banks and drifting snow, replaced by red dirt and dust that coats most everything and keeps a layer of haze across the skyline.

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Warm temperatures and dusty red roads weren't the only thing to greet me.  What I found in Kampala was group of collaborators from Uganda and the University of Minnesota who are working here to answer the unanswered questions of some of the most aggressive and common infectious diseases here; from cryptococcal meningitis to severe malaria. Some have been here for months, others a few years or their entire life.  As the newcomer to the team, here only for a week now, I look forward to taking it all in and helping where I can.


Monday, April 2, 2012

Shapiro In Bugobero

The following was written by Miriam Shapiro, 3rd year pediatric resident at University of Minnesota.



The rains have started here in eastern Uganda. The storms can be brief and, despite the significant amount of rain that comes down, the red dirt soaks it up in little time, leaving just a hint that it was here at all - the scent of dampness, a few puddles, a bit less dirt kicked up on the roads as we drive.



I am working at a rural health center in a village called Bugobero. It is about a 45-minute drive along these red dirt roads from Mbale, the largest city in the area. My primary task here is a clinical investigation of a syndrome of malaria, severe anemia and hematuria.



Though both severe anemia and hematuria are known complications of malaria, they were being seen at an increased frequency and with increased mortality in January and February of this year.






The health center in Bugobero is unique because it was adopted by an American health care NGO, which has partnered with the government to improve care delivery. Because of the extra funds provided through the NGO, the clinic is able to hire more staff and have a more reliable and wider supply of medications. The community has responded to the increase in services with a huge increase in patient visits.





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The health center includes adult and pediatric inpatient wards, a
maternity ward, an operating theater and a steady stream of outpatients
seen daily on a first-come, first-served basis. It is now drawing
patients from all around the vicinity.

The health center has one doctor, who spends most of his time working on surgical cases, and is otherwise staffed by clinical officers, midwives, nurses and nursing assistants.



There is a laboratory here, which can do rapid HIV tests, thick blood smears for malaria, urine microscopy and urine dip stick. Usually they can do hemoglobin estimates, but of late have run out of the slides required to run the test. This limitation has required that I rely more heavily on history and physical exam findings than ever before. It also means there are several children here whose diseases fall outside the ability of the health center to diagnose or treat, even if they were diagnosed properly.



Our primary role here has been the malaria investigation, though we also see patients on the pediatric ward and outpatients, as time allows. Though the numbers of patients are not huge, the investigation is taking much of our time because, in addition to taking histories from the patients' parents and doing physical exams, we also draw the blood samples and prepare the thin smear slides. We also must leave from Bugobero early enough each day to deliver the samples to the research laboratory and have them run prior to its closing time. Because we are relying on an outside laboratory, we rarely get results back in time for them to be relevant to clinical care.



It is a stark contrast to the help we get in the hospitals in the U.S. - write an order and (usually) our work is done. Here, we rely heavily on the nurses and nursing assistants for aid in translation. Few of the villagers speak enough English to get through the detailed interview, and medical records as we know them do not exist. Each patient has a small notebook that is usually purchased upon arrival to the clinic, though occasionally is brought from home with information from previous clinic/hospital visits. When we are lucky, we can read about half of what is written in the notebook; generally the amount of clinical documentation is minimal.



Occasionally we are asked to see a child who is particularly sick. Last week, it was a 6 year-old boy with pneumonia who presented in severe respiratory distress. By the time we were called, they had already put him on supplemental oxygen via the one concentrator available. Despite the oxygen, he remained tachypneic and in significant distress, with an O2 saturation in the mid-80s. He was given a dose of ceftriaxone, which is sometimes present in small supply, and given fluids. The oxygen concentrator was then required in the operating theater, so he was taken off oxygen.



Given his persistent distress, the decision was made to transfer the child to the district hospital in Mbale, where hopefully more resources would be available. We made the 45-minute drive with him in the backseat, off oxygen; by the time we reached Mbale, his saturation was down to 59%. He was admitted in Mbale, placed on oxygen (delivered by an intranasal catheter, which was not very effective; at least at first, his O2 sat had only increased a small amount).



When we checked on him again later, it turned out that the hospital was out of the drugs that they had prescribed for him, so he wasn't actually getting them. We went to the pharmacy, purchased more ceftriaxone and paracetamol and brought it back. While we were there, the power went out, which meant that the oxygen also went off. In the end, this child was not getting much more at the district hospital than he was at the health center. Despite it all, he steadily improved, and a couple days later was asking for chapattis.

Sometimes these stories end well.



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Miriam Shapiro poses with some children at the health center in Bugobero.